Adequacy of two versus three sputum specimens for the diagnosis of pulmonary tuberculosis

Ashwini Kumar, and Indira Bairy, and Chythra , R. Rao and Vishnu Prasad, and Sanjay Pattanshetty, and Charmaine Minoli Samarasinghe, (2009) Adequacy of two versus three sputum specimens for the diagnosis of pulmonary tuberculosis Natl Med J India, 22. pp. 298-299.

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"Background. The new guidelines issued by the Revised National Tuberculosis Control Programme for diagnosis of smear-positive tuberculosis recommend examination of only 2 sputum smears. We did a retrospective analysis of data from a designated microscopy centre to ascertain the diagnostic yield of 2 smears and the additional yield provided by the third smear. Methods. Data were obtained from the designated microscopy centre attached to our medical college. A total of 3257 patients with suspected tuberculosis had undergone sputum examination between September 2004 and March 2009. However, only 1762 of them had 3 sputum specimens examined. Data were entered and analysed using SPSS version 11.5. Results. Among the 1762 suspected patients, positivity in any 2 samples was found to be 17.7% while 19% were found to be positive in a single smear. A statistically insignificant association was found between the grading and positivity of the sputum samples using McNemar test. A positive third sample was found in 309 patients. If the first 2 samples were negative, the possibility of missing a third positive sample was 0.4%. Conclusion. Under field conditions, 2 sputum smears are as effective as 3 smears for diagnosing smear-positive tuberculosis.

Item Type: Article
Uncontrolled Keywords: Two Versus Three Sputum Specimens, Diagnosis, Pulmonary Tuberculosis
Subjects: Tuberculosis > Operations Research
Institutions: Zonal Task Force-State Task Force
Depositing User: admin
Date Deposited: 04 Mar 2013 12:30
Last Modified: 06 Mar 2013 11:52

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