Comparison of various measures of sensitivity of M. Tuberculosis to ethambutol

Subbammal, S. and Nair, N. G. K. and Radhakrishna, S. and Tripathy, S. P. (1978) Comparison of various measures of sensitivity of M. Tuberculosis to ethambutol Tubercle, 59. pp. 185-191.

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Abstract

A sensitivity test for ethambutol was standardised, and performed on cultures isolated from patients before and after the start of chemotherapy with ethambutol and isoniazid. A discrimination type of approach was employed and three criteria of resistance were evolved: (a) growth of 20 colonies or more on ethambutol 4 μg/ml, using a standard inoculum; (b) a proportion of 25% or more on ethambutol 1.4 μg/ml; (c) a proportion of 5% or more on ethambutol 2 μg/ml. The MIC definition appears to be the best in view of its simplicity and insensitivity of the classification (as sensitive or resistant) to variations in inoculum size.

Item Type: Article
Uncontrolled Keywords: Sensitivity Test, M. Tuberculosis, Ethambutol
Subjects: Tuberculosis > Laboratory
Institutions: National Institute for Research in Tuberculosis (NIRT), Chennai
Depositing User: admin
Date Deposited: 25 Feb 2013 12:12
Last Modified: 25 Feb 2013 12:12
URI: http://tbresearch.ntiindia.org.in/id/eprint/486

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