A qualitative test for the determination of isoniazid acetylator phenotype

Sarma, G. R. and Kannapiran, M. and Narayana, A. S. L. and Radhakrishna, S. (1978) A qualitative test for the determination of isoniazid acetylator phenotype Indian J Med Res, 68. pp. 335-340.

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Abstract

A qualitative test procedure for phenotyping isoniazid acetylators is described. It is based on a colour reaction which depends on the free sulphadimidine content in the total urine excreted over any one-hour period between 21 and 26 hours following a dose of sulphadimidine 1.0 or 1.5 g, depending on body-weight. The test correctly classified 96 per cent of 109 slow and 96 per cent of 68 rapid inactivators. Storage of urine samples at room-temperature up to 14 days did not affect the accuracy of the results.

Item Type: Article
Uncontrolled Keywords: Qualitative Test, Phenotyping Isoniazid Acetylators, Sulphadimidine
Subjects: Tuberculosis > Laboratory
Institutions: National Institute for Research in Tuberculosis (NIRT), Chennai
Depositing User: admin
Date Deposited: 25 Feb 2013 11:48
Last Modified: 25 Feb 2013 11:48
URI: http://tbresearch.ntiindia.org.in/id/eprint/485

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