Prevalence and early attack rate of tuberculosis among close family contacts of tuberculous patients in South India under domiciliary treatment with isoniazid plus PAS or isoniazid alone

Ramakrishnan, C. V. and Andrews, R. H. and Devadatta, S. and Fox, W. and Radhakrishna, S. and Somasundaram, P. R. and Velu, S. (1961) Prevalence and early attack rate of tuberculosis among close family contacts of tuberculous patients in South India under domiciliary treatment with isoniazid plus PAS or isoniazid alone Bull World Health Organ, 25. pp. 361-407.

[img] Text
26.pdf - Published Version
Restricted to Registered users only

Download (1475Kb)

Abstract

The authors present a report from the Tuberculosis Chemotherapy Centre, Madras, on the prevalence and attack rate of tuberculosis among close family contacts of tuberculous patients in South India undergoing domiciliary chemotherapy either with isoniazid plus PAS or with one of three regimens of isoniazid alone. This report gives (a) the prevalence of tuberculosis among the contacts at the time of diagnosis of the disease in the patients and (b) the incidence of tuberculosis in the contacts during the first year of treatment of the patients. The contacts were divided into four series, corresponding to the four chemotherapeutic regimens of the patients. The prevalence of active tuberculosis was found to be particularly high among children under five years of age, being 12.0% as compared with 7.6% for all age groups combined. The incidence of active tuberculosis during the year of treatment of the patients was also found to be highest in the under five years age-group - a further indication that child contacts are especially vulnerable to infection. The incidence was considerably higher in the first quarter of the year than in the other quarters, and it was lowest in the last quarter. This finding, together with the fact that the attack rates in the four contact series were not related either to the duration of bacteriological positivity in the patients or to the period of excretion of isoniazid-resistant organisms by the patients, suggests that the major risk to contacts in the first year results from exposure to the patient before treatment rather than from exposure during treatment. These results confirm the findings in an earlier study by the Centre of the contacts of patients in a controlled comparison of chemotherapy with isoniazid plus PAS at home and in sanatorium.

Item Type: Article
Uncontrolled Keywords: Tuberculosis, Prevalence, Attack Rate, Close Family Contacts, Domiciliary Treatment, South India
Subjects: Tuberculosis > Epidemiology
Institutions: National Institute for Research in Tuberculosis (NIRT), Chennai
Depositing User: admin
Date Deposited: 22 Feb 2013 06:54
Last Modified: 22 Feb 2013 06:54
URI: http://tbresearch.ntiindia.org.in/id/eprint/336

Actions (login required)

View Item View Item