The virulence in the Guinea pig of tubercle bacilli isolated before treatment from South Indian patients with pulmonary tuberculosis, 3. Virulence related to Pretreatment Status of Disease and to Response to Chemotherapy

Ramakrishnan, C. V. and Bhatia, A. L. and Fox, W. and Mitchison, D. A. and Radhakrishna, S. and Selkon, J. B. and Subbaiah, T. V. and Velu, S. and Wallace, J. G. (1961) The virulence in the Guinea pig of tubercle bacilli isolated before treatment from South Indian patients with pulmonary tuberculosis, 3. Virulence related to Pretreatment Status of Disease and to Response to Chemotherapy Bull World Health Organ, 25. pp. 323-338.

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Abstract

This is the last of a series of three reports from the Tuberculosis Research Centre, Madras, on a study undertaken with the object of finding out whether differences in the virulence in the guinea-pig of tubercle bacilli isolated from South Indian tuberculous patients before the start of chemotherapy are related to the severity of the patients disease on admission to treatment and to the subsequent response to chemotherapy. The 281 patients in this study were drawn from the patients admitted to a 1-year comparison of four domiciliary chemotherapeutic regimens: (a) 3.9-5.5 mg/kg isoniazid plus 0.2-0.3 g/kg sodium PAS daily, divided into two doses (PH series); (b) 7.8-9.6 mg/kg isoniazid alone daily in one dose (HI-1 series); (c) 7.8-9.6 mg/kg isoniazid alone daily, divided into two doses HI-2 series); (d) 3.9-5.5 mg/kg isoniazid alone daily, divided into two doses(H series). No evidence was found of an association between the virulence of the organisms and any pretreatment condition of known prognostic importance. There was no association between pretreatment virulence and progress during treatment in the PH series (the most effective regimen). In the other series, however, the progress was more satisfactory in patients infected with organisms of low virulence than in those infected with organisms of high virulence, the association between virulence and progress attaining statistical significance in the combined HI-2 and H series (the least effective regimens) and only just failing to do so in the smaller HI-1 series. Possible explanations are put forward both for the absence of an association between virulence and severity of disease on admission and for the presence of an association between virulence and response in the patients treated with isoniazid alone.

Item Type: Article
Uncontrolled Keywords: Pulmonary Tuberculosis, Virulence, Tubercle Bacilli, South Indian Patients
Subjects: Tuberculosis > Laboratory
Institutions: National Institute for Research in Tuberculosis (NIRT), Chennai
Depositing User: admin
Date Deposited: 22 Feb 2013 06:32
Last Modified: 22 Feb 2013 06:33
URI: http://tbresearch.ntiindia.org.in/id/eprint/334

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