Unfavourable outcomes among patients with MDR-TB on the standard 24-month regimen in Maharashtra, India

Suryawanshi, S. L. and Shewade, H. D. and Nagaraja, S. B. and Nair, S. A. and Parmar, M. (2017) Unfavourable outcomes among patients with MDR-TB on the standard 24-month regimen in Maharashtra, India PHA, 7 (2). pp. 116-122.

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Official URL: http://dx.doi.org/10.5588/pha.17.0013


Setting: Patients with multidrug-resistant tuberculosis (MDR-TB) registered for treatment (2011–2012 cohort) using the standard 24-month regimen, under the Revised National TB Control Programme's programmatic management of drug-resistant TB (PMDT), Maharashtra, India. Objectives: To assess the treatment outcomes and the timing and risk factors for unfavourable treatment outcomes, with a focus on death and loss to follow-up (LTFU). Method: This was a retrospective cohort study involving a review of PMDT records. Treatment outcomes were reported on 31 December 2014. Results: Of 4024 patients, treatment success was recorded in 1168 (29%). Unfavourable outcomes occurred in 2242 (56%), of whom 857 (21%) died and 768 (19%) were lost to follow-up. Treatment outcomes were missing on record review for 375 (9%) patients, and 239 (6%) were still undergoing treatment. Half of LTFU occurred within 3 months, and more than four fifths of deaths occurred after 6 months of treatment. Human immunodeficiency virus infection, being underweight, age ⩾ 15 years, male sex and pulmonary TB were the main risk factors for death, LTFU or other unfavourable treatment outcomes. Conclusion: The study found poor treatment outcomes in patients with MDR-TB registered for treatment in Maharashtra, India. Interventions are required to address the high rates of LTFU and death.

Item Type: Article
Uncontrolled Keywords: Multidrug-resistant tuberculosis; Loss to follow-up; Death; Operational research; India
Subjects: Tuberculosis > Operations Research
Tuberculosis > Drug Resistant TB
Institutions: National Task Force, Zonal Task Force & State Task Force of Medical Colleges
Depositing User: Mr SANJAY SINGH
Date Deposited: 31 Oct 2017 20:45
Last Modified: 31 Oct 2017 20:45
URI: http://tbresearch.ntiindia.org.in/id/eprint/2332

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