Household food insecurity is associated with low interferon-gamma levels in pregnant Indian women

Vaidya, A. and Bhosale, R. and Sambarey, P. and Suryavanshi, N. and Young, S. and Mave, V. and Kanade, S. and Kulkarni, V. and Deshpande, P. and Balasubramanian, U. and Elf, J. and Gupte, N. and Gupta, A. and Mathad, J. S. (2017) Household food insecurity is associated with low interferon-gamma levels in pregnant Indian women Int J Tuberc Lung Dis, 21 (7). pp. 797-803.

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Official URL: http://dx.doi.org/10.5588/ijtld.16.0718

Abstract

SETTING: Over 20% of tuberculosis (TB) cases during pregnancy occur in India. OBJECTIVE: To determine the association between household food insecurity and interferon-gamma (IFN-γ) levels in pregnancy. DESIGN: Pregnant women in India were administered the Household Food Insecurity Access Scale (HFIAS) questionnaire and underwent an IFN-γ release assay. Logistic regression was used to identify factors associated with food insecurity. RESULTS: Of 538 women, 60 (11%) had household food insecurity, 47 (78%) of which were moderate or severe food insecure. After mitogen stimulation, moderate or severe food insecure women had a median IFN-γ concentration of 4.2 IU/ml (IQR 2.2-9.8) vs. 8.4 IU/ml (IQR 3.0-10) in women with no or mild food insecurity (P = 0.03). In multivariate analysis, higher IFN-γ concentrations were associated with human immunodeficiency virus infection (OR 1.3, 95%CI 0.51-2.1, P = 0.001), and inversely associated with moderate or severe food insecurity (OR -1.6, 95%CI -2.9 to -0.27, P = 0.02) and the number of adults in the household (OR -0.08, 95%CI -0.16 to -0.01, P = 0.03). There was no association between food insecurity and IFN-γ response to Mycobacterium tuberculosis antigen. CONCLUSION: Food insecurity in pregnancy is associated with low IFN-γ levels. There was no association between food insecurity and IFN-γ response to M. tuberculosis antigen, but our study was underpowered to detect this outcome.

Item Type: Article
Uncontrolled Keywords: Interferon-gamma; Mitogen; TB antigen; QGIT
Subjects: Tuberculosis > Clinical
Tuberculosis > Epidemiology
Institutions: National Task Force, Zonal Task Force & State Task Force of Medical Colleges
Depositing User: Mr SANJAY SINGH
Date Deposited: 26 Oct 2017 00:58
Last Modified: 26 Oct 2017 00:58
URI: http://tbresearch.ntiindia.org.in/id/eprint/2323

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