Distribution and association of Mycobacterium tuberculosis CAS lineage with multidrug resistance in North India

Dhatwalia, S. K. and Yadav, R. and Behera, D. and Rudramurthy, S. M. and Kaur, H. and Sethi, S. (2016) Distribution and association of Mycobacterium tuberculosis CAS lineage with multidrug resistance in North India Int J Tuberc Lung Dis, 20 (6). pp. 806-811.

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Abstract

SETTING: A tertiary care hospital in North India. OBJECTIVES: To determine the prevalence of different genotypes and examine their association with drug resistance among clinical isolates of Mycobacterium tuberculosis from the northern region of India. DESIGN: We analysed 100 clinical isolates of M. tuberculosis using mycobacterial interspersed repetitive units genotyping and TbD1 analysis. RESULTS: The analysis revealed that 34% of strains belonged to the Delhi/CAS (TbD1-) lineage, 32% had unknown patterns (27 TbD1-, 5 TbD1+), 18% were of Beijing genotype (TbD1-) and 11% were of EAI lineages (TbD1+). Twenty-one strains were multidrug-resistant tuberculosis (MDR-TB), 9 of which belonged to the Delhi/CAS lineage, 4 were of Beijing lineage, 6 were of unknown pattern and one was of EAI lineage. Our meta-analysis showed the overall proportion of CAS lineage to be 42.96% (95%CI 33-52); the CAS lineage had no association with MDR-TB (OR 0.89, 95%CI 0.66-1.20). CONCLUSION: The study highlights the high proportion of CAS lineage strains and absence of association with MDR-TB. The distribution and identification of different genotypes of M. tuberculosis could help in better understanding the factors that influence disease transmission and drug resistance.

Item Type: Article
Uncontrolled Keywords: Tuberculosis; Molecular epidemiology; MIRU-VNTR; Drug resistance; Meta-analysis
Subjects: Tuberculosis > Drug Resistant TB
Institutions: National Task Force, Zonal Task Force & State Task Force of Medical Colleges
Depositing User: Mr SANJAY SINGH
Date Deposited: 26 Oct 2016 10:07
Last Modified: 26 Oct 2016 10:16
URI: http://tbresearch.ntiindia.org.in/id/eprint/2229

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