Tuberculous lymphadenopathy: a multicentre operational study of 6-month thrice weekly directly observed treatment

Jindal, S. K. and Aggarwal, A. N. and Gupta, D. and Ahmed, Z. and Gupta, K. B. and Janmeja, A. K. and Kashyap, S. and Singh, M. and Mohan, A. and Whig, J. (2013) Tuberculous lymphadenopathy: a multicentre operational study of 6-month thrice weekly directly observed treatment Int J Tuberc Lung Dis, 17 (2). pp. 234-239.

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Abstract

SETTING: Eight operational locations for the Revised National Tuberculosis Control Programme in six Indian states. OBJECTIVE: To assess the 6-month efficacy of an intermittent thrice-weekly directly observed treatment (DOT) regimen for tuberculous peripheral adenopathy and the need for prolongation of treatment to 9 months for non-resolution of lymphadenopathy. DESIGN: Patients aged >5 years with tuberculous lymphadenopathy were included in the study. Patients were evaluated for resolution at repeat visits following treatment. Those with poor resolution at 6 months were randomised to extended treatment up to 9 months or observation without additional treatment. RESULTS: Resolution of lymphadenopathy was observed at the end of 6 months in 517/551 (93.8%) patients. There was a significant difference in response among patients with and those without the presence of systemic symptoms. There was no association between treatment response and number, size, site, consistency and matting of lymphadenopathy. No differences in response were seen in the remaining 34 patients with or without extended treatment. CONCLUSION: The operational efficacy of 6-month thrice-weekly DOT for peripheral tubercular lymphadenopathy was satisfactory. There was no evidence of additional benefits of prolonging treatment to 9 months.

Item Type: Article
Uncontrolled Keywords: Lymphadenopathy; Tuberculosis; Intermittent therapy; Revised National Tuberculosis Control Programme; Directly Observed Treatment
Subjects: Tuberculosis > Extra Pulmonary TB
Institutions: Zonal Task Force-State Task Force
Depositing User: Mr SANJAY SINGH
Date Deposited: 31 Jan 2014 11:29
Last Modified: 31 Jan 2014 11:29
URI: http://tbresearch.ntiindia.org.in/id/eprint/1572

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